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Endocrine Abstracts

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ea0099oc4.4 | Oral Communications 4: Diabetes, Obesity, Metabolism and Nutrition | Part I | ECE2024

Sphinganine increases GLP-1 secretion and causes weight loss in mice

Smits Mark , Drzazga Anna , Galsgaard Katrine , Lackman Jarkko , Gerdes Victor , van de Laar Arnold , Bruin Sjoerd , Rosenkilde Mette , Holst Jens J.

Recent years have demonstrated increasing focus on augmenting secretion of glucagon-like peptide (GLP)-1 from intestinal L cells, to improve the treatment and/or prevention of obesity and type 2 diabetes. However, finding strong stimuli and identifying novel compounds has proven difficult. To discover new GLP-1 secretagogues, we gave 49 individuals (76% female, BMI 28.3±4.8 kg/m2) a high-fat liquid mixed meal (250 mL Nutridrink, Nutricia®). Plasma samples,...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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